Current lab members

  • Chris Bailey-Kellogg
  • Ryan Amos
  • Yoonjoo Choi
  • Srivamshi Pittala
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Fall 2016: Problem Solving (CS 10)
CS 10

Recent papers

  • Antibody humanization by structure-based computational protein design
  • Depleting T cell epitopes in lysostpahin mitigates anti-drug antibody responses and enhances antibacterial efficacy in vivo
  • Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance
  • Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees
  • Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries
  • Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate

[more...]

News

Dec 16Postdoctoral positions available in computationally-directed design of vaccines and protein therapeutics
Nov 16Congratulations to Yoonjoo and Deep, whose detailed description of our EpiSweep software suite is published in a Methods in Molecular Biology volume on computational protein design, as "EpiSweep: Computationally Driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity While Maintaining Function"
Nov 16The NIH will be further supporting our work in developing new ways to kill bad bugs, with an R01 grant "Co-opting endogenous pathogen autolysins as next generation antibiotics" (K. Griswold, PI)
Oct 16Our paper "Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects" has been accepted to J. Immunol.

[more...]

Contact

cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250
603-646-3385