Current lab members

  • Chris Bailey-Kellogg
  • Yoonjoo Choi
  • Karen Dowell
  • Lu He
  • Li Jiang
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Fall 2014: Bioinformatics (CS 75/175) Winter 2015: Computational immunology (CS 89/189)
CS 75/175 CS 89/189

Recent papers

  • Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines
  • Stoichiometries and affinities of interacting proteins from concentration series of solution scattering data:  Decomposition by least squares and quadratic optimization
  • Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage
  • Learning sequence determinants of protein:protein interaction specificity with sparse graphical models
  • Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers
  • Improved Multiple Sequence Alignments using Coupled Pattern Mining

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News

Sep 14We contributed to a couple new papers: "Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function" (AIDS; Chung & Alter) and "HCV Epitope, Homologous to Multiple Human Protein Sequences, Induces a Regulatory T Cell Response in Infected Patients" (J. Hepatol.; Losikoff & Gregory).
Aug 14Congratulations to Dr. Lu He, who successfully defended her dissertation "Computational Methods for the Discovery and Application of Protein Sequence-Structure-Function Relationships"

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Contact

cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250
603-646-3385