Current lab members

  • Chris Bailey-Kellogg
  • Yoonjoo Choi
  • Andrew O'Laughlin
  • Chris Park
  • Srivamshi Pittala
  • ~Neerja Thakkar
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Spring 2017: Computational immunology (CS 89/189)
CS 89/189

Recent papers

  • Antibody humanization by structure-based computational protein design
  • Depleting T cell epitopes in lysostpahin mitigates anti-drug antibody responses and enhances antibacterial efficacy in vivo
  • Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance
  • Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees
  • Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries
  • Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate

[more...]

News

Jan 17The NIH is helping us ramp up our efforts to develop lysostaphin to treat MRSA, with a Phase II academic-commercial partnership (STTR) with Lyticon: "Design and Development of Immunotolerant S. aureus Biotherapies"
Jan 17The NIH will be supporting our antibody epitope analysis work with a new collaborative grant with Ben Brooks (Wasatch Microfluidics) and Gary Cohen (Penn): "High-throughput, multiplexed characterization and modeling of antibody:antigen binding, with application to HSV"
Jan 17Chris is speaking at PepTalk 2017 on "Computationally Driven Identification of Antibody Epitopes"
Jan 17Congratulations and welcome to Neerja Thakkar, who was awarded a Sophomore Science Scholarship to work on "Clustering complementarity determining regions of T cell receptor repertoires"
Jan 17Welcome to Chris Park, who will be doing his senior thesis research with us.
Dec 16Chris is speaking at a meeting on "Computational drug development for biologics" on "Enhancing Therapeutic Efficacy Through The Computationally-Driven Depletion Of T Cell Epitopes"
Dec 16Postdoctoral positions available in computationally-directed design of vaccines and protein therapeutics
Dec 16Welcome to Andrew O'Laughlin, who is joining the lab to conduct his PhD research

[more...]

Contact

cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250
603-646-3385