Current lab members

  • Chris Bailey-Kellogg
  • Amelia Antrim
  • Yoonjoo Choi
  • Karen Dowell
  • Lu He
  • Li Jiang
  • Liane Makatura
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Spring 2014: Probabilistic Graphical Models (CS 89/189)
CS 89/189

Recent papers

  • Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines
  • Stoichiometries and affinities of interacting proteins from concentration series of solution scattering data:  Decomposition by least squares and quadratic optimization
  • Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage
  • Learning sequence determinants of protein:protein interaction specificity with sparse graphical models
  • Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers
  • Improved Multiple Sequence Alignments using Coupled Pattern Mining

[more...]

News

Mar 14Congratulations to movie star Regina (Karl Griswold's lab) whose video "A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes" is available in J Vis Exp
Mar 14Welcome to Amelia Antrim, who will be doing her senior thesis on B cell epitopes
Mar 14Congratulations to Amy (Galit Alter's lab) et al., whose paper "Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines" is out in Sci Transl Med
Mar 14Chris is speaking at the New Technologies, New Vaccines conference
Mar 14Congratulations to Lu, whose IcoVax paper "Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage" is now published in BMC Bioinf
Mar 14Congratulations to Himanshu, whose paper "Stoichiometries and affinities of interacting proteins from concentration series of solution scattering data: Decomposition by least squares and quadratic optimization" was accepted to J Appl Cryst
Feb 14Congratulations to Hongliang and Kristina (Karl Griswold's lab), whose paper "Gene and protein sequence optimization for high level production of fully active and aglycosylated lysostaphin in Pichia pastoris" was accepted to Applied and Environmental Microbiology

[more...]

Contact

cbk -at- cs -dot- dartmouth -dot- edu
Sudikoff Lab (Maynard & College), room 250
603-646-3385