This course will study algorithmic challenges in analyzing biomolecular sequences (what genes encode an organism, and how are genes related across organisms?), structures (what do the proteins constructed for these genes look like, and what does that tell us about their mechanisms?), and functions (what do these things do, and how do they interact with each other in doing it?).
This is HIV-1 protease on drugs -- any questions?
![]() | Kamisetty et al., "Modeling and inference of sequence-structure specificity", Proc. CSB, 2009 |
![]() | Kavathekar et al., "Characterizing the space of interatomic distance distribution functions consistent with solution scattering data", Proc. CSB, 2009 |
![]() | Thomas et al., "Graphical models of protein-protein interaction specificity from correlated mutations and interaction data", Proteins, 2009 |
![]() | Zheng et al., "Protein fragment swapping: a method for asymmetric, selective site-directed recombination", Proc. RECOMB, 2009 |
![]() | Thomas et al. "Protein design by sampling an undirected graphical model of residue constraints", IEEE/ACM TCBB, 2009 |
| Sep 09 | Welcome back to Nan Zheng, who was awarded a Presidential Scholarship to continue the protein graphical model visualization work she began as a WISP intern. |
| Aug 09 | The NSF is supporting our proposal "Algorithmic Problems in Protein Structure Studies", collaborative with Gopal Pandurangan. |
| Aug 09 | Welcome to new lab member Lu He. She's currently developing algorithms for optimizing protein recombination. |
| Aug 09 | The NSF is supporting our proposal "Integration, Prediction, and Generation of Mixed Mode Information using Graphical Models, with Applications to Protein-Protein Interactions", collaborative with Naren Ramakrishnan, Chris Langmead, and Alan Friedman. |
| Aug 09 | CSB-09 proceedings are available, including Hetu and Bornika's paper on sequence+structure graphical models, and Paritosh's on solution scattering. |