Current lab members

  • Chris Bailey-Kellogg
  • Ryan Amos
  • Yoonjoo Choi
  • Srivamshi Pittala
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Spring 2016: Problem Solving (CS 10)
CS 10

Recent papers

  • Antibody humanization by structure-based computational protein design
  • Depleting T cell epitopes in lysostpahin mitigates anti-drug antibody responses and enhances antibacterial efficacy in vivo
  • Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance
  • Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees
  • Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries
  • Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate

[more...]

News

Jun 16The NIH is further supporting our development of anti-staph therapies with an R21 grant "Engineer bifunctional antibacterial enzymes for treatment of S. aureus infections" (K. Griswold, PI)
Jun 16Congratulations to Deep, who was selected to give an oral presentaiton at 3dsig, on his work "Designing small HIV-1 antigens by protein peeling and rewiring techniques"
Jun 16Our review article "Design and Engineering of Deimmunized Biotherapeutics" was accepted for publication in Current Opinion in Structural Biology
Jun 16Congratulations to Ryan, who will be graduating with "High Honors" due in part to his outstanding thesis research. He will next join the PhD program at Princeton.
May 16Congratulations to Yoonjoo, whose paper "Computationally-Driven Antibody Engineering Enables Simultaneous Humanization and Thermostabilization" was accepted for publication in PEDS
Apr 16We will be doing some fun computational modeling as part of the just-funded NIH P01 grant "Bridging Antibody Fc-mediated Antiviral Functions across Humans and Non-human Primates" (PI: G. Tomaras, Duke)

[more...]

Contact

cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250
603-646-3385