Current lab members

  • Chris Bailey-Kellogg
  • Yoonjoo Choi
  • Karen Dowell
  • Lu He
  • Li Jiang
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Winter 2014: Problem Solving (CS 10)
CS 10

Recent papers

  • Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines
  • Stoichiometries and affinities of interacting proteins from concentration series of solution scattering data:  Decomposition by least squares and quadratic optimization
  • Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage
  • Learning sequence determinants of protein:protein interaction specificity with sparse graphical models
  • Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers
  • Improved Multiple Sequence Alignments using Coupled Pattern Mining



Mar 15Congratulations to Matt, who finished off his senior thesis and is heading down to work with the Talkowski lab at MGH
Mar 15Welcome to first-year CS PhD student Srivamshi Pittala, who will do a research project with us this spring
Feb 15The NIH has awarded an STTR grant to us and our good friends at Stealth Biologics, to continue the development of lysostaphin, a potent anti-staphylococcal enzyme
Feb 15Congratulations to Ickwon, whose paper "Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees" was accepted to PLOS Computational Biology
Jan 15Congratulations to Regina, Yoonjoo, et al., whose paper "Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads" was accepted to Biotechnology and Bioengineering
Jan 15Congratulations to Deep, whose paper "Structure-based Design of Combinatorial Mutagenesis Libraries" was accepted to Protein Science



cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250