Current lab members

  • Chris Bailey-Kellogg
  • Ryan Amos
  • Yoonjoo Choi
  • Karen Dowell
  • Jai Woo Lee
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Spring 2015: Problem Solving (CS 10)
CS 10

Recent papers

  • Depleting T cell epitopes in lysostpahin mitigates anti-drug antibody responses and enhances antibacterial efficacy in vivo
  • Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance
  • Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees
  • Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries.
Structure-based design of combinatorial mutagenesis libraries
  • Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate
  • Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

[more...]

News

Jul 15Chris is speaking at the Bioeconomy 2015 conference
Jul 15Yoonjoo is speaking at the Gordon Conference on Computer-Aided Drug Design
Jul 15Congratulations to Yoonjoo, along with Casey Hua (Margie Ackerman's lab), whose paper "Antibody Humanization by Structure-Based Computational Protein Design" has been accepted for publication in mAbs
Jun 15Congratulations to Jean Zhou and Jessie Anderson, both of whom have been selected as Sophomore Science Scholars to pursue research with us
May 15Some interviews and press about our lysostaphin work: VPR, WNNE, ACS Noteworthy Chemistry, Chemical & Engineering News

[more...]

Contact

cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250
603-646-3385