Current lab members

  • Chris Bailey-Kellogg
  • Yoonjoo Choi
  • Karen Dowell
  • Lu He
  • Li Jiang
  • Deeptak Verma

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

Winter 2015: Computational immunology (CS 89/189)
CS 89/189

Recent papers

  • Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines
  • Stoichiometries and affinities of interacting proteins from concentration series of solution scattering data:  Decomposition by least squares and quadratic optimization
  • Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage
  • Learning sequence determinants of protein:protein interaction specificity with sparse graphical models
  • Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers
  • Improved Multiple Sequence Alignments using Coupled Pattern Mining

[more...]

News

Jan 15Congratulations to Regina, Yoonjoo, et al., whose paper "Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads" was accepted to Biotechnology and Bioengineering
Jan 15Congratulations to Deep, whose paper "Structure-based Design of Combinatorial Mutagenesis Libraries" was accepted to Protein Science
Dec 14Congratulations to Ryan, who was awarded the Francis L. Town Prize Scientific Prize in Computer Science.
Nov 14Welcome to QBS PhD student Mavra Nasir, who will be rotating in the lab this winter
Nov 14Congratulations to Regina, Andrew, et al., whose paper "Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate" was accepted to PLOS Computational Biology
Nov 14Welcome to Jean Zhou, who will be doing a WISP internship on anti-HIV antibodies

[more...]

Contact

cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250
603-646-3385