Current lab members

  • Chris Bailey-Kellogg
  • Himanshu Chandola
  • Ickwon Choi
  • Yoonjoo Choi
  • Lu He
  • Tuobin Wang

Highlighted projects

  • deimmunization
  • graphical models
  • oligomer
  • recombination
  • multimodal
  • nmr

On sabbatical academic year 2011-2012.

Recent papers

  • Algorithms for optimizing cross-overs in DNA shuffling
  • NMR structural inference of symmetric homo-oligomers
  • A graphical method for analyzing distance restraints for structure determination of symmetric protein homo-oligomers
  • Optimization of therapeutic proteins to delete T-cell epitopes while maintaining beneficial residue interactions
  • Optimization of combinatorial mutagenesis
  • Accounting for conformational entropy in predicting binding free energies of protein-protein interactions

[more...]

News

May 12Welcome to Dr. Ickwon Choi, who is joining us as a postdoc after finishing his PhD at Case Western / Cleveland Clinic, working with Dr. Michael Kattan.
Apr 12Congratulations again to Tuobin, whose algorithmic work for our phosphoproteomics collaboration with Scott Gerber has yielded a paper to appear in Bioinformatics: "MMFPh: A Maximal Motif Finder for Phosphoproteomics Datasets"
Apr 12Congratulations to Tuobin, whose phosphoproteomics work in collaboration with Scott Gerber has yielded a paper to appear in Chemistry & Biology: "Rapid determination of multiple linear kinase substrate motifs by mass spectrometry"
Apr 12Congratulations to Dr. Andrew Scott Parker, who successfully defended his PhD dissertation "Combinatorial optimization methods for the design of deimmunized protein therapeutics"
Mar 12Lu's DNA shuffling paper is out in BMC BIoinformatics

[more...]

Contact

cbk -at- cs -dot- dartmouth -dot- edu
Sudikoff Lab (Maynard & College), room 250
603-646-3385