Current lab members

  • Chris Bailey-Kellogg
  • Andrew O'Laughlin
  • Bowen Dai
  • Daniel Mattox
  • Natalia Syzochenko
  • ~Neerja Thakkar
  • Srivamshi Pittala

Highlighted projects

  • deimmunization
  • antibody effector functions
  • MHC:peptide:TCR
  • graphical models
  • recombination
  • oligomer

Current/upcoming classes

2018-19 academic year: Research leave

Recent papers

  • Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV
  • Pareto optimization of combinatorial mutagenesis libraries
  • DisruPPI: Structure-based computational redesign algorithm for protein binding disruption
  • High-resolution definition of humoral immune response correlates of effective immunity against HIV
  • Computationally-driven identification of antibody epitopes
  • Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity

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News

Sep 18Congratulations to Srivamshi, along with collaborators in Margie Ackerman's lab and Galit Alter's lab and others, for a Nature Medicine paper appearing today: "Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV"
Aug 18Congratulations to Daniel, who was awarded a Burroughs Wellcome Fund: Big Data in the Life Sciences fellowship
Aug 18Congratulations to Arij Elfaki and Sahaj Shah, who were awarded Sophomore Science Scholarships to do research with us this year
Jul 18Congratulations to Deep, whose paper "Pareto optimization of combinatorial mutagenesis libraries" has now come out in IEEE TCBB
Jul 18We anticipate an additional postdoc position in computationally-directed immune engineering, and welcome applications now

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Contact

cbk -at- cs -dot- dartmouth -dot- edu
6211 Sudikoff Lab, Hanover, NH 03755, USA
Sudikoff Lab (corner of Maynard & College), room 250
603-646-3385