In collaboration with Annie De Groot and the Institute for Immunology & Informatics, we are developing new immunoinformatics methods to assess immunogenicity, evaluate potential cross-reactivity, and design better vaccines. Stay tuned as concrete results begin to emerge, building upon my sabbatical at ICubed.
Papers
- A.H. Guttierez, W.D. Martin, C. Bailey-Kellogg, F. Terry, L. Moise, and A.S. De Groot, "Development and validation of an epitope prediction tool for swine (PigMatrix) based on the pocket profile method", BMC Bioinf., 2015, 16:290. [abstract] [pubmed]
- L. He, A.S. De Groot, and C. Bailey-Kellogg, "Hit-and-run, hit-and-stay, and commensal bacteria present different peptide content when viewed from the perspective of the T cell", Vaccines, 2015, 33:6922-6999. [abstract] [pubmed]
- P.T. Losikoff, S. Mishra, F. Terry F, A. Gutierrez, M.T. Ardito, L. Fast, M. Nevola, W.D. Martin WD2, C. Bailey-Kellogg, A.S. De Groot, and S.H. Gregory , "HCV Epitope, Homologous to Multiple Human Protein Sequences, Induces a Regulatory T Cell Response in Infected Patients", J. Hepatol., 2014, 62:48-55. [abstract] [pubmed]
- L. He, A.S. De Groot, A.H Gutierrez, W.D. Martin, L. Moise, and C. Bailey-Kellogg, "Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage", BMC BIoinf., 2014, 15(Suppl 4):S1. [abstract] [pubmed]
- C. Bailey-Kellogg, A.H. Gutierrez, L. Moise, F. Terry, W.D. Martin, and A.S. De Groot, "CHOPPI: A web tool for the analysis of immunogenicity risk from host cell proteins in CHO-based protein production", Biotechnol. Bioeng., 2014, in press. [abstract]
- L. He, A.S. De Groot, A.H Gutierrez, W.D. Martin, L. Moise, and C. Bailey-Kellogg, "Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage", BMC BIoinf., 2014, 15(Suppl 4):S1. [abstract]
- L. Moise, A.H. Gutierrez, C. Bailey-Kellogg, F. Terry, Q. Leng, K.M. Abdel Hady, N.C. Verberkmoes, M.B. Sztein, P.T. Losikoff, W.D. Martin, A.L. Rothman, A.S. De Groot, "The two-faced T cell epitope: Examining the host-microbe interface with JanusMatrix", Hum Vaccin Immunother, 2013, 9:1577-1586. [abstract]