We have packaged up the code and examples accompanying the Methods in Molecular Biology chapter entitled "EpiSweep: Computationally-driven reengineering of therapeutic proteins to reduce immunogenicity while maintaining function" (pubmed). The code goes hand-in-hand with the description in the book chapter, which details the necessary modeling steps, the optimization process, and the analysis of the resulting designs to select those for experimental evaluation. The software is available for academic use by contacting the corresponding author.