In general, my lab's research focuses on integrated computational-experimental approaches to the structural and functional understanding of and control over the molecular machinery of the cell. We are developing algorithms and systems to automatically plan experiments, predict outcomes, interpret data, revise models, and so forth. The figures point to pages with high-level descriptions of some of our current projects.
This work is funded in part by the following:
- NIH R01: "Functional deimmunization of therapeutic proteins", PIs: Chris Bailey-Kellogg and Karl Griswold (Dartmouth Engineering), 2011-2020
- NIH R01: "Co-opting endogenous pathogen autolysins and next generation antibiotics", PI Karl Griswold (Dartmouth Engineering), 2016-2021
- NIH R21: "Engineer bifunctional antibacterial enzymes for treatment of S. aureus infections", PI: Karl Griswold (Dartmouth Engineering), 2016-2018
- NIH P01: "Bridging Antibody Fc-mediated Antiviral Functions Across Humans and Non-human Primates", PI: Georgia Tomaras (Duke), 2016-2021
- NIH STTR: "Design and Development of Immunotolerant S. aureus Biotherapies", PIs: Chris Bailey-Kellogg (Stealth Biologics, LLC) and Karl Griswold (Dartmouth Engineering), 2015-2018
- Gates Foundation CAVD grant: "Defining Signatures of Antibody Responses that Correlate with Protection to Develop Down-Selection Criteria to Guide Vaccine Candidate Selection", PIs: Margie Ackerman (Dartmouth Engineering) and Galit Alter (MGH)
- Gates Foundation grant: "IgG Fc Assessment Services", PI: David Montefiori (Duke)
We gratefully acknowledge previous support from the following:
- NIH R21: "Computationally optimized anti-staphylococcal biotherapeutics", collaborative with Karl Griswold (Dartmouth Engineering) and Annie De Groot (Institute for Immunology and Informatics), 2012-2014.
- Subcontract from Partners Healthcare System for the Gates Foundation Collaboration for AIDS Vaccine Discovery "High-throughput technology for assessing antibody effector function", PIs: Margie Ackerman (Dartmouth Engineering) and Galit Alter (Ragon Institute), 2011-2014.
- NSF III grant "Analysis of multi-dimensional protein design spaces with Pareto optimization of experimental designs", collaborative with Alan Friedman (Purdue), 2010-2013.
- NSF CCF grant "Algorithmic problems in protein structure studies", collaborative with Gopal Pandurangan (NTU Singapore), 2009-2012.
- NSF III grant "Integration, prediction, and generation of mixed mode information using graphical models, with applications to protein-protein interactions", collaborative with Naren Ramakrishnan (Va. Tech), Chris Langmead (CMU), and Alan Friedman (Purdue), 2009-2012.
- Comp-X grant from the Neukom Institute, to C. Bailey-Kellogg and K. Griswold (Engineering, Dartmouth), 2009-2010.
- Alfred P. Sloan Research Fellowship, to C. Bailey-Kellogg, 2005-2009.
- NSF SEIII grant: "Integration of multimodal experiments for protein structure", to C. Bailey-Kellogg, B.A. Craig (Statistics, Purdue) and A.M. Friedman (Biological Sciences, Purdue), 2004-2008.
- NSF CAREER award: "Sparse spatial reasoning for high-throughput protein structure determination", to C. Bailey-Kellogg, 2003-2008.
- An award from the Showalter Foundation: "Distribution functions of standard free energies of protein-protein association", to C. Bailey-Kellogg and M. Laskowski (Chemistry, Purdue), 2003-2004.
- A grant from Purdue's Computing Research Institute, through the PRF-SIRG program: "Multimodal discrimination of protein fold", to C. Bailey-Kellogg and A. Friedman (Biological Sciences, Purdue), 2003-2004.